ATX-Gx™ Platform

Royalty-free, best-in-class humanized transgenic mice discovery platform optimized for human antibody sequence developability and diversity, with a robust immune response comparable to wild-type mice.

TRUSTED BY 150 PARTNERS AND COUNTING

License the world’s most popular humanized mice antibody discovery platform

Originally invented and validated inside a major pharma company then further developed by Alloy, our foundational suite of highly immunocompetent transgenic mice is engineered to drive the greatest potential diversity of unique human antibodies binding to your target of interest, with broad epitopic coverage. The antibodies produced exhibit high affinity, requiring little-to-no optimization.

Accessible Terms

Our simple, royalty-free licensing process makes this foundational technology accessible to drug discovery teams of all sizes, with the know-how needed to achieve the best results.

Continuous Innovation

Partners can access our expanding portfolio of transgenic strains designed to address a range of discovery challenges, with the additional option of bespoke strains custom-tailored to your project.

Rich Discovery Output

The platform exhibits healthy cellularity, human-like repertoire, and robust immune response upon immunization. Its proven, rich discovery output offers wide epitopic coverage and a diverse range of binding affinity—and has a track record of success in difficult targets.

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AVAILABLE NOW

Larger organs make lymphoid organs easier to extract
Increased cell output gives peace of mind for precious samples, allowing user to test multiple arms of enrichment
Improved seroconversion kinetics compared to ATX-GK and WT mice
Enhanced IgM to IgG class-switching during B cell differentiation
Full human antibody repertoire incorporated

ATX-Gx Validation Data

Generating High-Quality Human Antibodies

The ATX-Gx humanized mice produce a robust immune response, with immune repertoires similar to wild-type (WT) animals and humans.

Serum Antibody Levels
Comparable to WT Mice

J-Gene Usage is Similar to Human Reference

CDR-H3 Distribution is Similar
to Human Repertoire

CASE STUDY

Diverse Antibody Output from the ATX-Gx platform

The ATX-Gx strain produced strong seroconversion levels by immunization with a recombinant protein target antigen.

ATX-GX Platform Produces Wild-Type Seroconversion Levels Resulting in a Highly Diverse Antibody Output

CASE STUDY

The ATX-Gx Platform Generates Rich Output of High-Affinity Binders

The ATX-Gx generates binders with a diverse range of affinity against different target antigens.

ATX-Gx Exhibits High Antibody Affinity Diversity

A proven strong track record of success in multiple target classes
Consistent generation of antibodies with single-digit nanomolar and subnanomolar affinities
Broad affinity range facilitates lead identification across different affinity regions

Multiple Strains for Superior Output

10 Strains Designed to Address Distinct Antibody Discovery Challenges

The ATX-Gx has expanded into a suite of 10 strains to offer our discovery partners the right tools to solve distinct antibody discovery challenges. Connect with our team of experts to determine the right ATX-Gx strain to meet your therapeutic goals.

Connect with Our Team

Core ATX-Gx Platform

Available via Alloy Antibody Discovery Services

THE RIGHT TOOLS

What can our suite of ATX-Gx strains do?

Improve immune response against a range of target antigens
Reduce immunodominance with non-overlapping VH germlines
Increase sequence and structural diversity of binders with Lambda light chains
Reduce central tolerance and broadening VDJ diversity
Enable FACS-based antibody discovery on both plasma and memory B cells
Enable efficient discovery human bispecific antibodies
Discover human VH for bispecifics and chimeric antigen receptors

Empower your antibody discovery with ATX-Gx

Get started with human antibody discovery in less than two weeks by licensing the ATX-Gx mice platform for use in your lab. Or, engage in a bespoke antibody discovery campaign with ATX-Gx platform experts through Alloy Antibody Discovery Services.

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Inquire About an ATX-Gx License

Targeting GPCRs with Alloy Antibody Discovery Services

Access the white paper

Thanks for your interest in our white paper, Targeting GPCRs with DeepImmune Antibody Discovery.

G protein-coupled receptors (GPCRs) play a central role in multiple physiological functions, from endocrine sensing to neurotransmission to chemotaxis of immune cells. This class has long been an attractive target for novel antibody drug discovery campaigns in multiple disease indications, but their unique nature produces many challenges for in vivo antibody discovery. In this white paper, we detail how our humanized mouse discovery platform, the ATX-Gx™, have been successfully utilized for GPCR-targeted antibody discovery, Alloy Antibody Discovery’s DeepImmune™ module builds on this robust in vivo discovery platform, coupling best-in-class immunogen production with multiple binder recovery approaches, and advanced machine-learning-based techniques for lead identification and optimization.

Keyway TCR Mimic Discovery Webinar

Access the webinar recording

I’d like more material about Keyway TCR Discovery

Thanks for your interest in our recent Keyway TCRm Discovery webinar, Increasing Target Specificity and Tackling Intracellular Targets for TCRm Therapeutics Development with Keyway’s TCRm Discovery Offering. In it, the team at the helm of our TCR mimic discovery campaigns shared:

1. An overview of common challenges to intracellular protein-targeting drug discovery
2. Keyway’s industry-leading solutions to TCRm/TCR-based therapeutic discovery including its proprietary specificity screening and high-quality pMHC complex antigen production capabilities
3. A case study featuring the discovery of a panel of highly specific, functional TCRm binders against an intracellular immuno-oncology target

Upon filling out this form, you will receive an email with a link to the webinar recording.

ATX-Gx™ Platform

TRUSTED BY 150 PARTNERS AND COUNTING

License the world’s most popular humanized mice antibody discovery platform

Accessible Terms

Continuous Innovation

Rich Discovery Output

AVAILABLE NOW

ATX-Gx Validation Data

Generating High-Quality Human Antibodies

Serum Antibody Levels Comparable to WT Mice

J-Gene Usage is Similar to Human Reference

CDR-H3 Distribution is Similar to Human Repertoire

CASE STUDY

Diverse Antibody Output from the ATX-Gx platform

ATX-GX Platform Produces Wild-Type Seroconversion Levels Resulting in a Highly Diverse Antibody Output

CASE STUDY

The ATX-Gx Platform Generates Rich Output of High-Affinity Binders

ATX-Gx Exhibits High Antibody Affinity Diversity

Multiple Strains for Superior Output

10 Strains Designed to Address Distinct Antibody Discovery Challenges

Core ATX-Gx Platform

Available via Alloy Antibody Discovery Services

THE RIGHT TOOLS

What can our suite of ATX-Gx strains do?

Empower your antibody discovery with ATX-Gx

Serum Antibody Levels
Comparable to WT Mice

CDR-H3 Distribution is Similar
to Human Repertoire